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Pharmacokinetic-pharmacodynamic modeling and simulation by Peter L Bonate, SpringerLink

Pharmacokinetic-pharmacodynamic modeling and simulation Peter L Bonate, SpringerLink ebook
Format: pdf
ISBN: 0387271996, 9780387271996
Publisher: Springer
Page: 394

By providing this infrastructure Devidas believes the partners can maximise the usefulness of pharmacokinetic/pharmacodynamic modeling and simulation (M&S) and increase its value in the drug development process. One of the authoritative texts on the subject. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting within-host parasite response was performed. This finding provides motivation for conducting more pharmacokinetic-pharmacodynamic (PK-PD) studies of artesunate to monitor its effectiveness and re-assess current dosing regimens. Results (preliminary): The Aarons L, Kyle DE, White NJ. WW 168 Op615 2012; The Oxford handbook of the history of medicine edited by Mark Jackson WZ 40 Ox982 2011; Pharmacokinetic-pharmacodynamic modeling and simulation Peter L. Pharmacokinetic-pharmacodynamic modeling and simulation. A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters. Pharmacokinetic-Pharmacodynamic Modeling and Simulation. Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. Designing these studies is The derived optimal designs were then evaluated via a simulation-estimation procedure. Part of these questions may be addressed through simulations from pharmacokinetic (PK) and pharmacodynamic (PD) models of HU. Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance.